Does changing the pulling direction give better insight into biomolecules?

Details Does changing the pulling direction give better insight into biomolecules? Does changing the pulling direction give better insight into biomolecules?

2007-01-27

arxiv.org/abs/cond-mat/0701679v1

Phys. Rev. Lett. 98, 048101 (2007)

Physics

Condensed Matter

Statistical Mechanics

RevTeX v4, 10 pages with 6 eps figures

Scientific paper

10.1103/PhysRevLett.98.048101

Single molecule manipulation techniques reveal that the mechanical resistance of a protein depends on the direction of the applied force. Using a lattice model of polymers, we show that changing the pulling direction leads to different phase diagrams. The simple model proposed here indicates that in one case the system undergoes a transition akin to the unzipping of a $\beta$ sheet, while in the other case the transition is of a shearing (slippage) nature. Our results are qualitatively similar to experimental results. This demonstrates the importance of varying the pulling direction since this may yield enhanced insights into the molecular interactions responsible for the stability of biomolecules.

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