Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
1998-07-13
Physics
Condensed Matter
Soft Condensed Matter
21 pages LATEX, 9 eps figures. Submitted to Biophysical Journal
Scientific paper
10.1016/S0006-3495(99)77334-0
Cooperativity plays an important role in the action of proteins bound to DNA. A simple, mechanical mechanism for cooperativity, in the form of a tension-mediated interaction between proteins bound to DNA at two different locations is proposed. These proteins are not in direct physical contact. DNA segments intercalating bound proteins are modeled as a Worm-Like Chain, which is free to deform in two dimensions. The tension-controlled protein-protein interaction is the consequence of two effects produced by the protein binding. The first is the introduction of a bend in the host DNA and the second is the modification of the bending modulus of the DNA in the immediate vicinity of the bound protein. The interaction between two bound proteins may be either attractive or repulsive, depending on their relative orientation on the DNA. Applied tension controls both the strength and the range of protein-protein interactions in this model. Properties of the cooperative interaction are discussed, along with experimental implications.
Bruinsma Robijn
Rudnick Joseph
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