DNA electrophoresis in designed channels

Details DNA electrophoresis in designed channels DNA electrophoresis in designed channels

2005-09-15

arxiv.org/abs/cond-mat/0509403v2

Physics

Condensed Matter

Soft Condensed Matter

11 pages, 8 figures

Scientific paper

10.1140/epje/i2005-10075-9

We present a simple description on the electrophoretic dynamics of polyelectrolytes going through designed channels with narrow constrictions of slit geometry. By analyzing rheological behaviours of the stuck chain, which is coupled to the effect of solvent flow, three critical electric fields (permeation field $E^{(per)} \sim N^{-1}$, deformation field $E^{(def)} \sim N^{-3/5}$ and injection field $E^{(inj)} \simeq N^0$, with $N$ polymerization index) are clarified. Between $E^{(per)}$ and $E^{(inj)}$, the chain migration is dictated by the driven activation process. In particular, at $E>E^{(def)}$, the stuck chain at the slit entrance is strongly deformed, which enhances the rate of the permeation. From these observations, electrophoretic mobility at a given electric field is deduced, which shows non-monotonic dependence on $N$. For long enough chains, mobility increases with $N$, in good agreement with experiments. An abrupt change in the electrophoretic flow at a threshold electric field is formally regarded as a nonequilibrium phase transition.

Affiliated with

Also associated with

No associations

Rating

DNA electrophoresis in designed channels does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with DNA electrophoresis in designed channels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA electrophoresis in designed channels will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-408673