Discrete charge patterns, Coulomb correlations and interactions in protein solutions

Details Discrete charge patterns, Coulomb correlations and interactions in protein solutions Discrete charge patterns, Coulomb correlations and interactions in protein solutions

2001-09-23

arxiv.org/abs/cond-mat/0109427v1

Physics

Condensed Matter

Soft Condensed Matter

4 twocolumn pages with 4 figures

Scientific paper

10.1209/epl/i2002-00524-7

The effective Coulomb interaction between globular proteins is calculated as a function of monovalent salt concentration $c_s$, by explicit Molecular Dynamics simulations of pairs of model proteins in the presence of microscopic co and counterions. For discrete charge patterns of monovalent sites on the surface, the resulting osmotic virial coefficient $B_2$ is found to be a strikingly non-monotonic function of $c_s$. The non-monotonicity follows from a subtle Coulomb correlation effect which is completely missed by conventional non-linear Poisson-Boltzmann theory and explains various experimental findings.

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