Direction dependent mechanical unfolding and Green Fluorescent Protein as a force sensor

Details Direction dependent mechanical unfolding and Green Fluorescent Protein as a force sensor Direction dependent mechanical unfolding and Green Fluorescent Protein as a force sensor

2011-07-21

arxiv.org/abs/1107.4188v1

Physical Review E 84, 021918 (2011)

Physics

Condensed Matter

Soft Condensed Matter

to appear in Phys Rev E

Scientific paper

10.1103/PhysRevE.84.021918

An Ising--like model of proteins is used to investigate the mechanical unfolding of the Green Fluorescent Protein along different directions. When the protein is pulled from its ends, we recover the major and minor unfolding pathways observed in experiments. Upon varying the pulling direction, we find the correct order of magnitude and ranking of the unfolding forces. Exploiting the direction dependence of the unfolding force at equilibrium, we propose a force sensor whose luminescence depends on the applied force.

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