Detachment of molecular motors under tangential loading

Details Detachment of molecular motors under tangential loading Detachment of molecular motors under tangential loading

2001-09-11

arxiv.org/abs/cond-mat/0109187v1

Physics

Condensed Matter

Statistical Mechanics

7 pages, 5 figures. To be published on Europhysics Letters

Scientific paper

10.1209/epl/i2001-00563-6

We introduce a general framework to study the processivity of molecular motors moving along a polar filament and discuss the average time spent attached to the filament as a function of a tangentially applied load. Our study of specific models suggests that the attachment time of a motor decreases with increasing ATP concentration and that double-headed motors such as kinesins lose their processivity under forcing conditions while processive single-headed motors are less sensitive to tangential forcing.

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