Denaturation transition of stretched DNA

Details Denaturation transition of stretched DNA Denaturation transition of stretched DNA

2007-09-19

arxiv.org/abs/0709.2958v2

Phys. Rev. Lett. 100, 018106 (2008)

Physics

Condensed Matter

Soft Condensed Matter

5 pages, 3 figures

Scientific paper

10.1103/PhysRevLett.100.018106

We generalize the Poland-Scheraga model to consider DNA denaturation in the presence of an external stretching force. We demonstrate the existence of a force-induced DNA denaturation transition and obtain the temperature-force phase diagram. The transition is determined by the loop exponent $c$ for which we find the new value $c=4\nu-1/2$ such that the transition is second order with $c=1.85<2$ in $d=3$. We show that a finite stretching force $F$ destabilizes DNA, corresponding to a lower melting temperature $T(F)$, in agreement with single-molecule DNA stretching experiments.

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