Denaturation of Heterogeneous DNA

Details Denaturation of Heterogeneous DNA Denaturation of Heterogeneous DNA

1997-01-16

arxiv.org/abs/cond-mat/9701117v3

Physics

Condensed Matter

Statistical Mechanics

4 pages, LaTeX, text and figures also available at http://matisse.ucsd.edu/~hwa

Scientific paper

10.1103/PhysRevLett.79.2375

The effect of heterogeneous sequence composition on the denaturation of double stranded DNA is investigated. The resulting pair-binding energy variation is found to have a negligible effect on the critical properties of the smooth second order melting transition in the simplest (Peyrard-Bishop) model. However, sequence heterogeneity is dramatically amplified upon adopting a more realistic treatment of the backbone stiffness. The model yields features of ``multi-step melting'' similar to those observed in experiments.

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