Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2007-12-17
Biophys. J. (Biophys. Lett.) 93, L49 (2007)
Physics
Condensed Matter
Soft Condensed Matter
3 pages, 1 figure
Scientific paper
10.1529/biophysj.107.119222
Recent experiments by Y. Gambin et al. [PNAS 103, 2098 (2006)] have called into question the applicability of the Saffman-Delbruck diffusivity for proteins embedded in the lipid bilayers. We present a simple argument to account for this observation that should be generically valid for a large class of transmembrane and membrane bound proteins. Whenever the protein-lipid interactions locally deform the membrane, that deformation generates new hydrodynamic stresses on the protein-membrane complex leading to a suppression of its mobility. We show that this suppression depends on the protein size in a manner consistent with the work of Y. Gambin et al.
Levine Alex J.
Naji Ali
Pincus Philip A.
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