Cooperativity of Protein Folding and the Random-Field Ising Model

Details Cooperativity of Protein Folding and the Random-Field Ising Model Cooperativity of Protein Folding and the Random-Field Ising Model

1996-06-18

arxiv.org/abs/cond-mat/9606136v1

Physics

Condensed Matter

Scientific paper

The relation between cooperativity of protein folding and the Random-Field Ising Model (RFIM) is established. Generalization of the Imry-Ma argument predicts cooperative folding transition for small heterogeneity of the interactions stabilizing the native structure. Monte Carlo simulation of a lattice model shows that starting from some finite heterogeneity folding transition is not cooperative and involves formation of domains.

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