Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles

Details Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles

2009-11-05

arxiv.org/abs/0911.1064v2

Phys. Rev. Lett. 103, 238102 (2009)

Physics

Condensed Matter

Soft Condensed Matter

5 pages, 3 figures, figure file has been corrected in v2

Scientific paper

We examine the mechanism of bundling of cytoskeletal actin filaments by two representative bundling proteins, fascin and espin. Small-angle X-ray studies show that increased binding from linkers drives a systematic \textit{overtwist} of actin filaments from their native state, which occurs in a linker-dependent fashion. Fascin bundles actin into a continuous spectrum of intermediate twist states, while espin only allows for untwisted actin filaments and fully-overtwisted bundles. Based on a coarse-grained, statistical model of protein binding, we show that the interplay between binding geometry and the intrinsic \textit{flexibility} of linkers mediates cooperative binding in the bundle. We attribute the respective continuous/discontinous bundling mechanisms of fascin/espin to differences in the stiffness of linker bonds themselves.

Affiliated with

Also associated with

No associations

Rating

Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-418330