Cooperative crosslink (un)binding in slowly driven bundles of semiflexible filaments

Details Cooperative crosslink (un)binding in slowly driven bundles of semiflexible filaments Cooperative crosslink (un)binding in slowly driven bundles of semiflexible filaments

2011-03-21

arxiv.org/abs/1103.4154v1

Phys. Rev. E 83, 050902(R) (2011)

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

10.1103/PhysRevE.83.050902

Combining simulations and theory I study the interplay between bundle elastic degrees of freedom and crosslink binding propensity. By slowly driving bundles into a deformed configuration, and depending on the mechanical stiffness of the crosslinking agent, the binding affinity is shown to display a sudden and discontinuous drop. This indicates a cooperative unbinding process that involves the crossing of a free-energy barrier. Choosing the proper crosslinker, therefore, not only allows to change the composite elastic properties of the bundle, but also the relevant time-scales, which can be tuned from the single-crosslink binding rate to the much longer escape time over the free-energy barrier.

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