Contractile stresses in cohesive cell layers on finite-thickness substrates

Details Contractile stresses in cohesive cell layers on finite-thickness substrates Contractile stresses in cohesive cell layers on finite-thickness substrates

2012-04-13

arxiv.org/abs/1204.3019v1

Physics

Condensed Matter

Soft Condensed Matter

5 pages, 4 figures

Scientific paper

Using a minimal model of cells or cohesive cell layers as continuum active elastic media, we examine the effect of substrate thickness and stiffness on traction forces exerted by strongly adhering cells. We obtain a simple expression for the length scale controlling the spatial variation of stresses in the cellular material in terms of cell and substrate parameters. Our model is an important step towards a unified theoretical description of the dependence of traction forces on cell or colony size, acto-myosin contractility, substrate depth and stiffness, and strength of focal adhesions, and makes experimentally testable predictions.

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