Complexation of DNA with Cationic Surfactant

Details Complexation of DNA with Cationic Surfactant Complexation of DNA with Cationic Surfactant

1999-04-30

arxiv.org/abs/cond-mat/9904447v1

Physics

Condensed Matter

9 pages, 3 figures

Scientific paper

10.1016/S0378-4371(99)00184-3

Transfection of an anionic polynucleotide through a negatively charged membrane is an important problem in genetic engineering. The direct association of cationic surfactant to DNA decreases the effective negative charge of the nucleic acid, allowing the DNA-surfactant complex to approach a negatively charged membrane. The paper develops a theory for solutions composed of polyelectrolyte, salt, and ionic surfactant. The theoretical predictions are compared with the experimental measurements.

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