Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2011-03-02
Physics
Condensed Matter
Soft Condensed Matter
6 pages, 4 figures, Phys. Rev. Lett. (in press)
Scientific paper
We establish a framework for assessing whether the transition state location of a biopolymer, which can be inferred from single molecule pulling experiments, corresponds to the ensemble of structures that have equal probability of reaching either the folded or unfolded states (Pfold = 0.5). Using results for the forced-unfolding of a RNA hairpin, an exactly soluble model and an analytic theory, we show that Pfold is solely determined by s, an experimentally measurable molecular tensegrity parameter, which is a ratio of the tensile force and a compaction force that stabilizes the folded state. Applications to folding landscapes of DNA hairpins and leucine zipper with two barriers provide a structural interpretation of single molecule experimental data. Our theory can be used to assess whether molecular extension is a good reaction coordinate using measured free energy profiles.
Hinczewski Michael
Hyeon Changbong
Morrison Greg
Thirumalai Dave
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