Comment on "Why is the DNA denaturation transition first order?"

Details Comment on "Why is the DNA denaturation transition first order?" Comment on "Why is the DNA denaturation transition first order?"

2001-10-09

arxiv.org/abs/cond-mat/0110164v2

Phys. Rev. Lett. 90, 159801 (2003)

Physics

Condensed Matter

Statistical Mechanics

1 page, REVTeX. Last paragraph added

Scientific paper

10.1103/PhysRevLett.90.159801

In this comment we argue that while the conclusions in the original paper (Y. Kafri, D. Mukamel and L. Peliti, Phys. Rev. Lett. 85, 4988 (2000)) are correct for asymptotically long DNA chains, they do not apply to the chains used in typical experiments. In the added last paragraph, we point out that for real DNA the average distance between denatured loops is not of the order of the persistence length of a single-stranded chain but much larger. This corroborates our reasoning that the double helix between loops is quite rigid, and thereby our conclusion.

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