Comment on "Pinched Flow Fractionation: Continuous Size Separation of Particles Utilizing a Laminar Flow Profile in a Pinched Microchannel"

Details Comment on "Pinched Flow Fractionation: Continuous Size Separation of Particles Utilizing a Laminar Flow Profile in a Pinched Microchannel" Comment on "Pinched Flow Fractionation: Continuous Size Separation of Particles Utilizing a Laminar Flow Profile in a Pinched Microchannel"

2007-10-31

arxiv.org/abs/0710.5840v1

Analytical Chemistry 79, 9240 (2007).

Physics

Fluid Dynamics

Comment on paper by Yamada et al. [Anal. Chem. 76(18), 5465 - 5471 (2004)]. Accepted for Anal. Chem

Scientific paper

10.1021/ac7018816

[First paragraph] In a recent paper Yamada et al. propose the novel concept of "pinched flow fractionation" (PFF) for the continuous size separation and analysis of particles in microfabricated lab-on-a-chip devices. In their description of the basic principle they claim that especially the width of the pinched and broadened segments will affect theseparation performance. In the following we comment on the physics behind this statement.

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