Physics – Condensed Matter – Disordered Systems and Neural Networks
Scientific paper
1999-05-10
Phys. Rev. Lett., v. 83, n. 22, pp. 4670-4673, 2000.
Physics
Condensed Matter
Disordered Systems and Neural Networks
4 pages, 4 figures
Scientific paper
10.1103/PhysRevLett.83.4670
In order to understand the nuclei which develop during the course of protein folding and unfolding, we examine phase segregation of a single heteropolymer chain which occurs in equilibrium. These segregated conformations are characterized by a nucleus of monomers which are superimposable upon the native conformation. We computationally generate the phase segregation by applying a ``folding pressure,'' or adding an energetic bonus for native monomer-monomer contacts. The computer models reveal a fundamental difference in the nucleation process between heteropolymeric and the more familiar vapor-liquid systems: in a polymer system, some nuclei hinder folding via topological constraints and must be partially destroyed in order for folding to proceed. To illustrate this finding, we examine the kinetics of protein unfolding in the long chain limit through scaling arguments. We find that because of the topological constraints, the critical nucleus size is of the order of the entire chain size so that unfolding time scales as $\exp [c N^{2/3} ]$, where $N$ and $c$ are the chain length and a constant.
Du Rui-Rui
Grosberg Alexander Yu.
Tanaka Toyoichi
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