Chromatin dynamics: Nucleosomes go mobile through twist defects

Details Chromatin dynamics: Nucleosomes go mobile through twist defects Chromatin dynamics: Nucleosomes go mobile through twist defects

2003-02-10

arxiv.org/abs/cond-mat/0302188v1

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 2 figures

Scientific paper

10.1103/PhysRevLett.91.148103

We study the spontaneous ''sliding'' of histone spools (nucleosomes) along DNA as a result of thermally activated single base pair twist defects. To this end we map the system onto a suitably extended Frenkel-Kontorova model. Combining results from several recent experiments we are able to estimate the nucleosome mobility without adjustable parameters. Our model shows also how the local mobility is intimately linked to the underlying base pair sequence.

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