Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction

Details Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction

2005-08-16

arxiv.org/abs/cond-mat/0508384v1

Proceedings of the National Academy of Sciences (2005) 102, 11600-11605

Physics

Condensed Matter

Materials Science

Scientific paper

Biological systems are known to be highly transparent to 700-1100nm near-infrared (NIR) light. It is shown here that the strong optical absorbance of single-walled carbon nanotubes (SWNTs) in this special spectral window, an intrinsic property of SWNTs, can be utilized for optical stimulation of nanotubes inside living cells to afford multifunctional nanotube biological transporters. For oligonucleotides transported inside living cells by nanotubes, the oligos can translocate into cell nucleus upon endosomal rupture triggered by NIR laser pulses. Continuous NIR radiation can cause cell death due to excessive local heating of SWNT in vitro. Selective cancer cell destruction can be achieved via functionalization of SWNT with a folate moiety, selective internalization of SWNTs inside cells labeled with folate receptor tumor-markers and NIR triggered cell death, without harming receptor-free normal cells. Thus, the transporting capabilities of carbon nanotubes combined with suitable functionalization chemistry and their intrinsic optical properties can lead to new classes of novel nanomaterials for drug delivery and cancer therapy.

Affiliated with

Also associated with

No associations

Rating

Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-138543