Physics – Condensed Matter – Statistical Mechanics
Scientific paper
2008-10-28
Physics
Condensed Matter
Statistical Mechanics
J. Stat. Mech. (Proceedings UPON2008)
Scientific paper
10.1088/1742-5468/2009/01/P01004
A stochastic model is here introduced to investigate the molecular mechanisms which trigger the perception of pain. The action of analgesic drug compounds is discussed in a dynamical context, where the competition with inactive species is explicitly accounted for. Finite size effects inevitably perturb the mean-field dynamics: Oscillations in the amount of bound receptors spontaneously manifest, driven by the noise which is intrinsic to the system under scrutiny. These effects are investigated both numerically, via stochastic simulations and analytically, through a large-size expansion. The claim that our findings could provide a consistent interpretative framework to explain the emergence of cyclic behaviors in response to analgesic treatments, is substantiated.
Fanelli Duccio
Patti Francesca Di
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