Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison

Details Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison

2010-05-04

arxiv.org/abs/1005.0640v1

Physics

Condensed Matter

Soft Condensed Matter

10 pages, 2 figures

Scientific paper

The advent of X-ray Free Electron Lasers promises the possibility to determine the structure of individual particles such as microcrystallites, viruses and biomolecules from single-shot diffraction snapshots obtained before the particle is destroyed by the intense femtosecond pulse. This program requires the ability to determine the orientation of the particle giving rise to each snapshot at signal levels as low as ~10-2 photons/pixel. Two apparently different approaches have recently demonstrated this capability. Here we show they represent different implementations of the same fundamental approach, and identify the primary factors limiting their performance.

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