Base Pair Openings and Temperature Dependence of DNA Flexibility

Details Base Pair Openings and Temperature Dependence of DNA Flexibility Base Pair Openings and Temperature Dependence of DNA Flexibility

2012-01-31

arxiv.org/abs/1201.6561v2

Phys. Rev. Lett. 108, 078104 (2012)

Physics

Condensed Matter

Statistical Mechanics

Scientific paper

10.1103/PhysRevLett.108.078104

The relationship of base pair openings to DNA flexibility is examined. Published experimental data on the temperature dependence of the persistence length by two different groups are well described in terms of an inhomogeneous Kratky-Porot model with soft and hard joints, corresponding to open and closed base pairs, and sequence-dependent statistical information about the state of each pair provided by a Peyrard-Bishop-Dauxois (PBD) model calculation with no freely adjustable parameters.

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