Adding a New Dimension to DNA Melting Curves

Details Adding a New Dimension to DNA Melting Curves Adding a New Dimension to DNA Melting Curves

2009-08-19

arxiv.org/abs/0908.2753v1

Europhysics Letters (EPL) 4, 87 (2009) 48009-1-6

Physics

Condensed Matter

Statistical Mechanics

to be published in Europhysics Letters

Scientific paper

10.1209/0295-5075/87/48009

Standard DNA melting curves record the separation of the two strands versus temperature, but they do not provide any information on the location of the opening. We introduce an experimental method which adds a new dimension to the melting curves of short DNA sequences by allowing us to record the degree of opening in several positions along the molecule all at once. This adds the spatial dimension to the melting curves and allows a precise investigation of the role of the base-pair sequence on the fluctuations and denaturation of the DNA double helix. We illustrate the power of the method by investigating the influence of an AT rich region on the fluctuations of neighboring domains.

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