Physics – Condensed Matter
Scientific paper
2003-04-15
Physics
Condensed Matter
13 pages, 7 figures
Scientific paper
Qualitative attributes of the region between order and disorder are examined to explore models of genetic and protein networks. Results show how the connectivity of vertices and the strength of their connections are related and how their stability is related to their geometry. It has been possible to relate the interaction energies and chemical potentials of general lattices with the coordination numbers of such lattice models. The results seem to agree with some of those obtained by means of other methods, e.g., those of Barabasi, Strognatz, Dorogovtsev, and Kauffman (BSDK). This can yield new perspectives to the cause, treatment and remedies of disease other than the present mode of drug discovery prevalent: the docking of a single ligand on to a target molecule. In order to utilize such results more efficiently, the pathway of biological processes need be elucidated. A method is available for determining biochemical-reaction or metabolic pathways through its systematic synthesis. It is based on a rigorous graph-theoretic method for identifying pathways of catalytic reactions. It synthesizes networks of metabolic pathways using a highly exacting combinatorial method. It generates not only all feasible, independent reaction networks but also those combinations of independent pathways. This method can determine the mechanisms of complex chemical reactions and is applicable to biochemical reactions. It is important to combine this result with the mechanisms existent in gene regulatory networks. Training Genetic Regulatory Networks for feasible biochemical reaction networks or pathways and incorporating such knowledge into DNA would be a superb technique for vanquishing complex diseases.
Bumble Stan
Fan L. T.
Friedler F.
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