A New Algorithm for Protein Design

Details A New Algorithm for Protein Design A New Algorithm for Protein Design

1995-08-28

arxiv.org/abs/cond-mat/9508127v1

Physics

Condensed Matter

10 pages latex 2.09 no figures. Use uufiles to decode

Scientific paper

10.1103/PhysRevLett.76.323

We apply a new approach to the reverse protein folding problem. Our method uses a minimization function in the design process which is different from the energy function used for folding. For a lattice model, we show that this new approach produces sequences that are likely to fold into desired structures. Our method is a significant improvement over previous attempts which used the energy function for designing sequences.

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