Physics – Condensed Matter – Materials Science
Scientific paper
2011-03-24
NANO Letters Volume: 9 Issue: 10 Pages: 3651-3657 (Oct 2009)
Physics
Condensed Matter
Materials Science
12 pages, 4 figures
Scientific paper
Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were non-cytotoxic, biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.
Goya Gerardo F.
Hoare Todd
Irusta Silvia
Kohane Daniel S.
Langer Robert
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