A Hierarchical Approach to Protein Molecular Evolution

Details A Hierarchical Approach to Protein Molecular Evolution A Hierarchical Approach to Protein Molecular Evolution

1999-03-21

arxiv.org/abs/cond-mat/9903310v1

Proc. Natl. Acad. Sci. USA 96 (1999) 2591-2595. Copyright PNAS

Physics

Condensed Matter

Statistical Mechanics

15 pages. 2 figures. LaTeX style

Scientific paper

10.1073/pnas.96.6.2591

Biological diversity has evolved despite the essentially infinite complexity of protein sequence space. We present a hierarchical approach to the efficient searching of this space and quantify the evolutionary potential of our approach with Monte Carlo simulations. These simulations demonstrate that non-homologous juxtaposition of encoded structure is the rate-limiting step in the production of new tertiary protein folds. Non-homologous ``swapping'' of low energy secondary structures increased the binding constant of a simulated protein by $\approx10^7$ relative to base substitution alone. Applications of our approach include the generation of new protein folds and modeling the molecular evolution of disease.

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