Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments

Details Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments

2011-05-04

arxiv.org/abs/1105.0710v2

Phys. Rev. Lett., 107:098102 (2011)

Physics

Condensed Matter

Statistical Mechanics

Scientific paper

10.1103/PhysRevLett.107.098102

To explain the observed dynamics in equilibrium single-molecule measurements of biomolecules, the experimental observable is often chosen as a putative reaction coordinate along which kinetic behavior is presumed to be governed by diffusive dynamics. Here, we invoke the splitting probability as a test of the suitability of such a proposed reaction coordinate. Comparison of the observed splitting probability with that computed from the kinetic model provides a simple test to reject poor reaction coordinates. We demonstrate this test for a force spectroscopy measurement of a DNA hairpin.

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