The binding dynamics of tropomyosin on actin

Details The binding dynamics of tropomyosin on actin The binding dynamics of tropomyosin on actin

2001-09-20

arxiv.org/abs/cond-mat/0109381v2

Biophys. J. 81, 3146-3155 (2001)

Physics

Condensed Matter

Soft Condensed Matter

REVTeX, 10 pages, 9 figures; to appear in Biophysical Journal; minor corrections

Scientific paper

10.1016/S0006-3495(01)75951-6

We discuss a theoretical model for the cooperative binding dynamics of tropomyosin to actin filaments. Tropomyosin binds to actin by occupying seven consecutive monomers. The model includes a strong attraction between attached tropomyosin molecules. We start with an empty lattice and show that the binding goes through several stages. The first stage represents fast initial binding and leaves many small vacancies between blocks of bound molecules. In the second stage the vacancies annihilate slowly as tropomyosin molecules detach and re-attach. Finally the system approaches equilibrium. Using a grain-growth model and a diffusion-coagulation model we give analytical approximations for the vacancy density in all regimes.

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