Physics – Condensed Matter – Statistical Mechanics
Scientific paper
1997-11-22
Physics
Condensed Matter
Statistical Mechanics
9 pages RevTeX, 3 eps-figures included, submitted to PRL
Scientific paper
10.1103/PhysRevLett.80.5015
The non-Markovian nature of polymer motions is accounted for in folding kinetics, using frequency-dependent friction. Folding, like many other problems in the physics of disordered systems, involves barrier crossing on a correlated energy landscape. A variational transition state theory (VTST) that reduces to the usual Bryngelson-Wolynes Kramers approach when the non-Markovian aspects are neglected is used to obtain the rate, without making any assumptions regarding the size of the barrier, or the memory time of the friction. The transformation to collective variables dependent on the dynamics of the system allows the theory to address the controversial issue of what are ``good'' reaction coordinates for folding.
Plotkin Steven S.
Wolynes Peter G.
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