Speeding protein folding beyond the Go model: How a little frustration sometimes helps

Details Speeding protein folding beyond the Go model: How a little frustration sometimes helps Speeding protein folding beyond the Go model: How a little frustration sometimes helps

2000-09-27

arxiv.org/abs/cond-mat/0009413v1

Physics

Condensed Matter

Disordered Systems and Neural Networks

12 pages, 5 figures, 1 table. submitted to Proteins: Struct. Funct. Genet

Scientific paper

Perturbing a Go model towards a realistic protein Hamiltonian by adding non-native interactions, we find that the folding rate is in general enhanced as ruggedness is initially increased, as long as the protein is sufficiently large and flexible. Eventually the rate drops rapidly towards zero when ruggedness significantly slows conformational transitions. Energy landscape arguments for thermodynamics and kinetics are coupled with a treatment of non-native collapse to elucidate this effect.

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