Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2009-12-10
J. Chem. Phys. 131, 065103 (2009)
Physics
Condensed Matter
Soft Condensed Matter
7 pages, 8 figures
Scientific paper
Effect of molecular crowding and confinement experienced by protein in the cell during unfolding has been studied by modeling a linear polymer chain on a percolation cluster. It is known that internal structure of the cell changes in time, however, they do not change significantly from their initial structure. In order to model this we introduce the correlation among the different disorder realizations. It was shown that the force-extension behavior for correlated disorder in both constant force ensemble (CFE) and constant distance ensemble (CDE) is significantly different than the one obtained in absence of molecular crowding.
Giri Debaprasad
Kumar Sanjay
Singh Amit Raj
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