Conditions for extreme sensitivity of protein diffusion in membranes to cell environments

Details Conditions for extreme sensitivity of protein diffusion in membranes to cell environments Conditions for extreme sensitivity of protein diffusion in membranes to cell environments

2006-08-11

arxiv.org/abs/cond-mat/0608288v2

Proc. Natl. Acad. Sci. USA 103 (2006) 15002

Physics

Condensed Matter

Soft Condensed Matter

19 pages, 4 figures

Scientific paper

10.1073/pnas.0606992103

We study protein diffusion in multicomponent lipid membranes close to a rigid substrate separated by a layer of viscous fluid. The large-distance, long-time asymptotics for Brownian motion are calculated using a nonlinear stochastic Navier-Stokes equation including the effect of friction with the substrate. The advective nonlinearity, neglected in previous treatments, gives only a small correction to the renormalized viscosity and diffusion coefficient at room temperature. We find, however, that in realistic multicomponent lipid mixtures, close to a critical point for phase separation, protein diffusion acquires a strong power-law dependence on temperature and the distance to the substrate $H$, making it much more sensitive to cell environment, unlike the logarithmic dependence on $H$ and very small thermal correction away from the critical point.

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