Instantons in the working memory: implications for schizophrenia

Details Instantons in the working memory: implications for schizophrenia Instantons in the working memory: implications for schizophrenia

1999-11-02

arxiv.org/abs/cond-mat/9911006v1

Physics

Condensed Matter

Disordered Systems and Neural Networks

Scientific paper

The influence of the synaptic channel properties on the stability of delayed activity maintained by recurrent neural network is studied. The duration of excitatory post-synaptic current (EPSC) is shown to be essential for the global stability of the delayed response. NMDA receptor channel is a much more reliable mediator of the reverberating activity than AMPA receptor, due to a longer EPSC. This allows to interpret the deterioration of working memory observed in the NMDA channel blockade experiments. The key mechanism leading to the decay of the delayed activity originates in the unreliability of the synaptic transmission. The optimum fluctuation of the synaptic conductances leading to the decay is identified. The decay time is calculated analytically and the result is confirmed computationally.

Affiliated with

Also associated with

No associations

Rating

Instantons in the working memory: implications for schizophrenia does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Instantons in the working memory: implications for schizophrenia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Instantons in the working memory: implications for schizophrenia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-553923