Thermodynamics of Heat Shock Response

Details Thermodynamics of Heat Shock Response Thermodynamics of Heat Shock Response

1999-12-22

arxiv.org/abs/cond-mat/9912402v1

Physics

Condensed Matter

To be published in Physical Review Letters

Scientific paper

10.1103/PhysRevLett.84.3005

Production of heat shock proteins are induced when a living cell is exposed to a rise in temperature. The heat shock response of protein DnaK synthesis in E.coli for temperature shifts from temperature T to T plus 7 degrees, respectively to T minus 7 degrees is measured as function of the initial temperature T. We observe a reversed heat shock at low T. The magnitude of the shock increases when one increase the distance to the temperature $T_0 \approx 23^o$, thereby mimicking the non monotous stability of proteins at low temperature. Further we found that the variation of the heat shock with T quantitatively follows the thermodynamic stability of proteins with temperature. This suggest that stability related to hot as well as cold unfolding of proteins is directly implemented in the biological control of protein folding. We demonstrate that such an implementation is possible in a minimalistic chemical network.

Affiliated with

Also associated with

No associations

Rating

Thermodynamics of Heat Shock Response does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Thermodynamics of Heat Shock Response, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thermodynamics of Heat Shock Response will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-518675