Sequence Effects on DNA Entropic Elasticity

Details Sequence Effects on DNA Entropic Elasticity Sequence Effects on DNA Entropic Elasticity

1997-11-26

arxiv.org/abs/cond-mat/9711285v1

Phys. Rev. Lett. 80 (1998) 5810

Physics

Condensed Matter

Soft Condensed Matter

LaTeX; postscript available at http://dept.physics.upenn.edu/~nelson/index.shtml

Scientific paper

10.1103/PhysRevLett.80.5810

DNA stretching experiments are usually interpreted using the worm-like chain model; the persistence length A appearing in the model is then interpreted as the elastic stiffness of the double helix. In fact the persistence length obtained by this method is a combination of bend stiffness and intrinsic bend effects reflecting sequence information, just as at zero stretching force. This observation resolves the discrepancy between the value of A measured in these experiments and the larger ``dynamic persistence length'' measured by other means. On the other hand, the twist persistence length deduced from torsionally-constrained stretching experiments suffers no such correction. Our calculation is very simple and analytic; it applies to DNA and other polymers with weak intrinsic disorder.

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