On the adhesion of particles to a cell layer under flow

Details On the adhesion of particles to a cell layer under flow On the adhesion of particles to a cell layer under flow

2007-08-10

arxiv.org/abs/0708.1447v1

Dans European Nano Systems Worshop - ENS 2006, Paris : France (2006)

Physics

Condensed Matter

Materials Science

Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions)

Scientific paper

The non-specific adhesion of spherical particles to a cell substrate is analyzed in a parallel plate flow chamber, addressing the effect of the particle size. Differently from other experiments, the total volume of the injected particles has been fixed, rather than the total number of particles, as the diameter d of the particles is changed from 500 nm up to 10 $\mu$m. From the analysis of the experimental data, simple and instructive scaling adhesion laws have been derived showing that (i) the number of particles adherent to the cell layer per unit surface decreases with the size of the particle as d^(-1.7) ; and consequently (ii) the volume of the particles adherent per unit surface increases with the size of the particles as d^(+1.3). These results are of importance in the "rational design" of nanoparticles for drug delivery and biomedical imaging.

Affiliated with

Also associated with

No associations

Rating

On the adhesion of particles to a cell layer under flow does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with On the adhesion of particles to a cell layer under flow, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and On the adhesion of particles to a cell layer under flow will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-46938