Force dependent fragility in RNA hairpins

Details Force dependent fragility in RNA hairpins Force dependent fragility in RNA hairpins

2006-06-09

arxiv.org/abs/cond-mat/0606254v1

Phys. Rev. Lett. vol. 96, 218301 (2006)

Physics

Condensed Matter

Soft Condensed Matter

Latex file, 4 pages+3 figures

Scientific paper

10.1103/PhysRevLett.96.218301

We apply Kramers theory to investigate the dissociation of multiple bonds under mechanical force and interpret experimental results for the unfolding/refolding force distributions of an RNA hairpin pulled at different loading rates using laser tweezers. We identify two different kinetic regimes depending on the range of forces explored during the unfolding and refolding process. The present approach extends the range of validity of the two-states approximation by providing a theoretical framework to reconstruct free-energy landscapes and identify force-induced structural changes in molecular transition states using single molecule pulling experiments. The method should be applicable to RNA hairpins with multiple kinetic barriers.

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