Physics – Condensed Matter – Statistical Mechanics
Scientific paper
2011-06-30
J.Chem.Phys 134, 014510 (2011)
Physics
Condensed Matter
Statistical Mechanics
17 pages, 18 figures
Scientific paper
10.1063/1.3518450
The interplay between cytoskeletal architecture and the nonlinearity of the interactions due to bucklable filaments plays a key role in modulating the cell's mechanical stability and affecting its structural rearrangements. We study a model of cytoskeletal structure treating it as an amorphous network of hard centers rigidly cross-linked by nonlinear elastic strings, neglecting the effects of motorization. Using simulations along with a self-consistent phonon method, we show that this minimal model exhibits diverse thermodynamically stable mechanical phases that depend on excluded volume, crosslink concentration, filament length and stiffness. Within the framework set by the free energy functional formulation and making use of the random first order transition theory of structural glasses, we further estimate the characteristic densities for a kinetic glass transition to occur in this model system. Network connectivity strongly modulates the transition boundaries between various equilibrium phases, as well as the kinetic glass transition density.
Shen Tongye
Wang Shenshen
Wolynes Peter G.
No associations
LandOfFree
The Interplay of Nonlinearity and Architecture in Equilibrium Cytoskeletal Mechanics does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with The Interplay of Nonlinearity and Architecture in Equilibrium Cytoskeletal Mechanics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The Interplay of Nonlinearity and Architecture in Equilibrium Cytoskeletal Mechanics will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-34757