Statistical Mechanics of Torque Induced Denaturation of DNA

Details Statistical Mechanics of Torque Induced Denaturation of DNA Statistical Mechanics of Torque Induced Denaturation of DNA

1999-04-20

arxiv.org/abs/cond-mat/9904277v2

Physics

Condensed Matter

Statistical Mechanics

5 pages, 3 figures, model improved

Scientific paper

10.1103/PhysRevLett.83.5178

A unifying theory of the denaturation transition of DNA, driven by temperature T or induced by an external mechanical torque Gamma is presented. Our model couples the hydrogen-bond opening and the untwisting of the helicoidal molecular structure. We show that denaturation corresponds to a first-order phase transition from B-DNA to d-DNA phases and that the coexistence region is naturally parametrized by the degree of supercoiling sigma. The denaturation free energy, the temperature dependence of the twist angle, the phase diagram in the T,Gamma plane and isotherms in the sigma, Gamma plane are calculated and show a good agreement with experimental data.

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