Nucleation and growth in one dimension, part II: Application to DNA replication kinetics

Details Nucleation and growth in one dimension, part II: Application to DNA replication kinetics Nucleation and growth in one dimension, part II: Application to DNA replication kinetics

2004-08-12

arxiv.org/abs/cond-mat/0408297v1

Physics

Condensed Matter

Soft Condensed Matter

8 pages, 6 figures

Scientific paper

10.1103/PhysRevE.71.011909

Inspired by recent experiments on DNA replication, we apply a one-dimensional nucleation-and-growth model to DNA-replication kinetics, focusing on how to extract the time-dependent nucleation rate I(t) and growth speed v from data. We discuss generic experimental problems, namely spatial inhomogeneity, measurement noise, and finite-size effects. After evaluating how each of these affects the measurements of I(t) and v, we give guidelines for the design of experiments. These ideas are then discussed in the context of the DNA-replication experiments.

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