Optimized free energies from bidirectional single-molecule force spectroscopy

Details Optimized free energies from bidirectional single-molecule force spectroscopy Optimized free energies from bidirectional single-molecule force spectroscopy

2008-02-02

arxiv.org/abs/0802.0224v2

Phys. Rev. Lett. 100, 180602 (2008)

Physics

Condensed Matter

Statistical Mechanics

4 pages, 2 figures

Scientific paper

10.1103/PhysRevLett.100.180602

An optimized method for estimating path-ensemble averages using data from processes driven in opposite directions is presented. Based on this estimator, bidirectional expressions for reconstructing free energies and potentials of mean force from single-molecule force spectroscopy - valid for biasing potentials of arbitrary stiffness - are developed. Numerical simulations on a model potential indicate that these methods perform better than unidirectional strategies.

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