Lethality and centrality in protein networks

Details Lethality and centrality in protein networks Lethality and centrality in protein networks

2001-05-15

arxiv.org/abs/cond-mat/0105306v1

Nature, v411 41-42 (2001)

Physics

Condensed Matter

Statistical Mechanics

See also http:/www.nd.edu/~networks and http:/www.nd.edu/~networks/cell

Scientific paper

10.1038/35075138

In this paper we present the first mathematical analysis of the protein interaction network found in the yeast, S. cerevisiae. We show that, (a) the identified protein network display a characteristic scale-free topology that demonstrate striking similarity to the inherent organization of metabolic networks in particular, and to that of robust and error-tolerant networks in general. (b) the likelihood that deletion of an individual gene product will prove lethal for the yeast cell clearly correlates with the number of interactions the protein has, meaning that highly-connected proteins are more likely to prove essential than proteins with low number of links to other proteins. These results suggest that a scale-free architecture is a generic property of cellular networks attributable to universal self-organizing principles of robust and error-tolerant networks and that will likely to represent a generic topology for protein-protein interactions.

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