RNA polymerase motors: dwell time distribution, velocity and dynamical phases

Details RNA polymerase motors: dwell time distribution, velocity and dynamical phases RNA polymerase motors: dwell time distribution, velocity and dynamical phases

2009-04-17

arxiv.org/abs/0904.2625v1

Physics

Condensed Matter

Statistical Mechanics

6 pages, 7 figures

Scientific paper

Polymerization of RNA from a template DNA is carried out by a molecular machine called RNA polymerase (RNAP). It also uses the template as a track on which it moves as a motor utilizing chemical energy input. The time it spends at each successive monomer of DNA is random; we derive the exact distribution of these "dwell times" in our model. The inverse of the mean dwell time satisfies a Michaelis-Menten-like equation and is also consistent with a general formula derived earlier by Fisher and Kolomeisky for molecular motors with unbranched mechano-chemical cycles. Often many RNAP motors move simultaneously on the same track. Incorporating the steric interactions among the RNAPs in our model, we also plot the three-dimensional phase diagram of our model for RNAP traffic using an extremum current hypothesis.

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