Physics – Chemical Physics
Scientific paper
2009-04-14
Physical Review Letters 103, 148103 (2009)
Physics
Chemical Physics
12 pages, 2 figures
Scientific paper
10.1103/PhysRevLett.103.148103
We show that the thermodynamic limit of a bistable phosphorylation-dephosphorylation cycle has a selection rule for the "more stable" macroscopic steady state. The analysis is akin to the Maxwell construction. Based on the chemical master equation approach, it is shown that, except at a critical point, bistability disappears in the stochastic model when fluctuation is sufficiently low but unneglectable. Onsager's Gaussian fluctuation theory applies to the unique macroscopic steady state. With initial state in the basin of attraction of the "less stable" steady state, the deterministic dynamics obtained by the Law of Mass Action is a metastable phenomenon. Stability and robustness in cell biology are stochastic concepts.
Ge Hao
Qian Hong
No associations
LandOfFree
Thermodynamic Limit of a Nonequilibrium Steady-State: Maxwell-Type Construction for a Bistable Biochemical System does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Thermodynamic Limit of a Nonequilibrium Steady-State: Maxwell-Type Construction for a Bistable Biochemical System, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thermodynamic Limit of a Nonequilibrium Steady-State: Maxwell-Type Construction for a Bistable Biochemical System will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-98320