Thermodynamic Limit of a Nonequilibrium Steady-State: Maxwell-Type Construction for a Bistable Biochemical System

Physics – Chemical Physics

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

12 pages, 2 figures

Scientific paper

10.1103/PhysRevLett.103.148103

We show that the thermodynamic limit of a bistable phosphorylation-dephosphorylation cycle has a selection rule for the "more stable" macroscopic steady state. The analysis is akin to the Maxwell construction. Based on the chemical master equation approach, it is shown that, except at a critical point, bistability disappears in the stochastic model when fluctuation is sufficiently low but unneglectable. Onsager's Gaussian fluctuation theory applies to the unique macroscopic steady state. With initial state in the basin of attraction of the "less stable" steady state, the deterministic dynamics obtained by the Law of Mass Action is a metastable phenomenon. Stability and robustness in cell biology are stochastic concepts.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Thermodynamic Limit of a Nonequilibrium Steady-State: Maxwell-Type Construction for a Bistable Biochemical System does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Thermodynamic Limit of a Nonequilibrium Steady-State: Maxwell-Type Construction for a Bistable Biochemical System, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thermodynamic Limit of a Nonequilibrium Steady-State: Maxwell-Type Construction for a Bistable Biochemical System will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-98320

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.