Polyphosphorylation and Non-Enzymatic Template-Directed Ligation of Oligonucleotides

Details Polyphosphorylation and Non-Enzymatic Template-Directed Ligation of Oligonucleotides Polyphosphorylation and Non-Enzymatic Template-Directed Ligation of Oligonucleotides

Jan 2000

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2000oleb...30...45g&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 30, Issue 1, p. 45-51 (2000).

Physics

1

Scientific paper

Oligonucleotide 5'-polyphosphates are formed under potentially prebiotic conditions from oligonucleotide 5'-phosphates and sodium trimetaphosphate. Oligonucleotides activated as polyphosphates undergo template-directed ligation. We believe that these reactions could have produced longer oligonucleotide products from shorter substrates under prebiotic conditions.

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