Maximum tolerable dose (MTD): a new index for ultraviolet radiation toxicity in the lens

Details Maximum tolerable dose (MTD): a new index for ultraviolet radiation toxicity in the lens Maximum tolerable dose (MTD): a new index for ultraviolet radiation toxicity in the lens

Jun 2001

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2001spie.4245..217s&link_type=abstract

Proc. SPIE Vol. 4245, p. 217-220, Ophthalmic Technologies XI, Fabrice Manns; Per G. Soederberg; Arthur Ho; Eds.

Physics

Scientific paper

The maximum tolerable dose (MTD2.3:16) for avoidance of cataract on exposure to UVR-300 nm in the rat was currently estimated to 3.65 kJ/m2. For this, Sprague-Dawley rats were unilaterally exposed to UVR in the 300 nm wavelength region, generated with a high pressure mercury arc source. The intensity of forward light scattering was measured one week after exposure. MTD allows estimation of toxicity for continuous response events with small sample experiments. Current safety standards for avoidance of cataract after exposure to UVR are based on a binary response event. It has however recently been shown that UVR-induced cataract is a continuous dose-dependent event. MTD provides a statistically well defined criterium of toxicity for continuous response events.

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