Electrokinetic control of sample splitting at a channel bifurcation using isotachophoresis

Details Electrokinetic control of sample splitting at a channel bifurcation using isotachophoresis Electrokinetic control of sample splitting at a channel bifurcation using isotachophoresis

Jul 2009

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2009njph...11g5026p&link_type=abstract

New Journal of Physics, Volume 11, Issue 7, pp. 075026 (2009).

Physics

Scientific paper

We present a novel method for accurately splitting ionic samples at microchannel bifurcations. We leverage isotachophoresis (ITP) to focus and transport sample through a one-inlet, two-outlet microchannel bifurcation. We actively control the proportion of splitting by controlling potentials at end-channel reservoirs (and thereby controlling the current ratio). We explore the effect of buffer chemistry and local electric field on splitting dynamics and propose and validate a simple Kirchoff-type rule controlling the split ratio. We explore the effects of large applied electric fields on sample splitting and attribute a loss of splitting accuracy to electrohydrodynamic instabilities. We propose a scaling analysis to characterize the onset of this instability. This scaling is potentially useful for other electrokinetic flow problems with self-sharpening interfaces.

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