Physics
Scientific paper
Dec 1984
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1984orli...14..477p&link_type=abstract
Origins of Life, Volume 14, Issue 1-4, pp. 477-484
Physics
Scientific paper
The water soluble carbodiimide mediated condensation of dipeptides of the general form Gly-X was carried out in the presence of mono- and poly-nucleotides. The observed yield of the tetrapeptide was found to be higher for peptide-nucleotide system of higher interaction specificity following mainly the anticodon-amino acid relationship (Basu, H.S. & Podder, S.K., 1981, Ind. J. Biochem. Biophys., 19, 251 253). The yield of the condensation product of L-peptide was more because of its higher interaction specificity. The extent of the racemization during the condensation of Gly-L-Phe, Gly-L-Tyr and Gly-D-Phe was found to be dependent on the specificity of the interaction —the higher the specificity, the lesser the racemization. The product formed was shown to have a catalytic effect on the condensation reaction. These data thus provide a mechanism showing how the specific interaction between amino acids/dipeptides and nucleic acids could lead to the formation of the ‘primitive’ translation machinery.
Basu H. S.
Podder S. K.
No associations
LandOfFree
Specificity of protein — Nucleic acid interaction and the biochemical evolution does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Specificity of protein — Nucleic acid interaction and the biochemical evolution, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Specificity of protein — Nucleic acid interaction and the biochemical evolution will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-739044